What are the mechanisms that govern the formation of amyloid protein structures associated with human diseases such as Alzheimer’s disease, Parkinson’s disease, type 2 diabetes, Prion diseases and systemic amyloidosis? This is a question of fundamental biological importance, and the focus of the research in Dr. Wei-Feng Xue's lab.

 

Dr Wei-Feng Xue is Senior Lecturer in Chemical biology in the School of Biosciences. He received his PhD degree in Physical Chemistry on research regarding protein-protein/protein-ligand interactions in Prof. Sara Linse’s group at Lund University in Sweden (2006). He then went on to do postdoctoral research concerning the mechanism and the biological impact of amyloid assembly in Prof. Sheena Radford’s laboratory at the Astbury Centre for Structural Molecular Biology in the University of Leeds (2006-2011). His research interests include supramolecular protein assembly, protein folding and misfolding, amyloid and prions, and AFM imaging. As a member of the KFG, he contributes his expertise in amyloid and prion biophysics to the group, and conduct research projects on the fundamental mechanisms of prion growth, propagation and transmission using S. cerevisiae yeast prion models.

 

Interested in joining us as Postdoc, PhD student or Research Masters student on research projects on amyloid biochemistry, protein biophysics, or imaging of biological structures? Contact: W.F.Xue@kent.ac.uk



Visit Wei-Feng's page on the University of Kent website​ and the Xue lab's Facebook page

List of Publications

Dr. Wei-Feng Xue

Ben Blakeman

Working on a project to characterise amyloid suprastructures, Ben is the resident AFM imaging expert. Having graduated with a first class degree in Biomedical Sciences, Ben is now completing his PhD in Biochemistry on a project to study the nano-scale properties of amyloid assembly. 

 

Cassie Mackenzie

Cassie is a Kent funded PhD student jointly advised with Prof. Mike Geeves in Biosciences. She is expert in AFM and biophysical methods to study proteins and her research interest is in the structure, function and folding of tropomyosin molecules.

Dr. Nadia Koloteva-Levine

Nadia is the yeast molecular and cellular biology expert in the group. Her research interests include the cellular impact of amyloid aggregation and prion propagation mechanisms. She is currently working on a BBSRC funded project looking into the molecular mechanism of amyloid cross-seeding.

Niken Pam

Niken is a Kent funded PhD student in the lab. She is working on a project to understand how molecular chaperones interact with amyloid aggregates and fragment amyloid fibrils to produce small transmissible seeds.

Rita Adriani

After completing a synthetic biology iGem project in the lab, Rita is now a postgraduate research student working on a project focused on characterising amyloid cross-seeding in vivo.

Saskia Davis

Saskia is a Kent graduate with degree in Biomedical Sciences. She is now a postgraduate research student focusing on studying the structure of amyloid assemblies using atomic force microscopy.

Tansy Vallintine

Tansy is a postgraduate research student jointly advised with Dr. Anastasios Tsaousis in Biosciences. She is looking at Cryptosporidium parasites structures using atomic force microscopy (AFM) and electron microscopy (EM).

Tracey Purton

As the research technician in the lab, Tracey manages the practical, health and safety, and many other general daily aspects in the lab. She is also the source of recombinant protein samples that everyone enjoy experimenting on in the lab. 

Please reload

Lab members

Past Lab members

Dr. David Beal

Dave originally trained as a chemist worked on a project to understand the fundamental mechanisms governing the mechanical stability of amyloid fibrils. He graduated from lab and obtained his PhD degree in 2016 and is now a postdoctoral researcher working in Prof. Mick Tuite's lab.

Dr. Ricardo Marchante

Ricardo is a skilled yeast molecular and cell biologist. As a postdoctoral research in the lab between 2012-2016, Ricardo worked on projects to resolve the infectious potential of amyloid particles using yeast prions as a model system. He has since moved city and model system, and he is now working in the University of Cologne on protein aggregation in nematode worm C. elegans.

Chloë Pain

Chloë worked on a project to understand how molecular chaperones interact with amyloid aggregates and fragment amyloid fibrils to produce small transmissible seeds in the lab between 2016-2017.

Blake Andrews

Blake is a Forensic Chemistry with a Year in Industry Graduate from the University of Kent. He carried out a Chemistry Research Masters project jointly advised with Dr. Chris Serpell in the School of Physical Sciences. His research interest is in designing novel templated amyloid fibril self-assemblies in order to control their shape and size.

Ioannis Emmanouilidis

Ioannis worked on a biophysical project to investigate the amyloid cross-seeding phenomenon during summer of 2017

Please reload

  • Wix Facebook page
  • Wix Twitter page
  • Flickr Classic

The KFG website is kindly sponsored by Formedium